Soluble Granzymes Are Released during Human Endotoxemia and in Patients with Severe Infection Due to Gram‐Negative Bacteria

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منابع مشابه

Soluble granzymes are released during human endotoxemia and in patients with severe infection due to gram-negative bacteria.

Extracellular release of granzymes is considered to reflect the involvement of cytotoxic T lymphocytes and NK cells in various disease states. To obtain insight into granzyme release during bacterial infection, granzyme levels were measured during experimental human endotoxemia and in patients with melioidosis, a severe infection due to gram-negative bacteria. Plasma concentrations of granzyme ...

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Lecithinase production by gramnegative bacteria.

Lecithinase production by microorganisms has been investigated in an attempt to use it in the classification of bacteria, and to associate formation with toxicity and virulence. The first record of this reaction was made when Nagler (1939) and Seifert (1939) observed, independently, the formation of an opalescence in human serum by the a toxin of Clostridium perfringens. It was soon found that ...

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Soluble Ligands for the NKG2D Receptor Are Released during Endometriosis and Correlate with Disease Severity

BACKGROUND Endometriosis is a benign gynaecological disease. Abundant bulk of evidence suggests that patients with endometriosis have an immunity dysfunction that enables ectopic endometrial cells to implant and proliferate. Previous studies show that natural killer cells have a pivotal role in the immune control of endometriosis. METHODS AND FINDINGS This is a prospective laboratory study co...

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High dose tigecycline in critically ill patients with severe infections due to multidrug-resistant bacteria

INTRODUCTION The high incidence of multidrug-resistant (MDR) bacteria among patients admitted to ICUs has determined an increase of tigecycline (TGC) use for the treatment of severe infections. Many concerns have been raised about the efficacy of this molecule and increased dosages have been proposed. Our purpose is to investigate TGC safety and efficacy at higher than standard doses. METHODS...

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ژورنال

عنوان ژورنال: The Journal of Infectious Diseases

سال: 2000

ISSN: 0022-1899,1537-6613

DOI: 10.1086/315642